ADF and 5:2 Studies

Where’s the science behind alternate day intermittent fasting and 5:2 fasting? We’re assembling Fast Days Healing Days list and hope you’ll help. In the early days, there will be many studies not shown on this page…please contact us and show us the study! If we think it’s useful information, we’ll add it to the growing list of studies!




Mar 2014 – Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population (Read Full Study)

4 March 2014 | Cell Metabolism | Volume 19, Issue 3, 407-417 | 10.1016/j.cmet.2014.02.006
Morgan E. Levine, Jorge Al Suarez, Sebastian Brandhorst, Pryla Balasubramanian, chia-Wei Cheng, Federica Madia, Luigi Fontana, Mario G. Mirisota, Jamie Guevara-Aguirre, Junxiang Wan, Giuseppe Passorino, Brian K. Kennedy, Min Wei, Pinchas Cohen, Eileen M. Crimmins, Valter D. Longo






Jan 2014 – Calories, carbohydrates, and cancer therapy with radiation: exploiting the five R’s through dietary manipulation

Cancer and Metastasis Reviews (January 2014)
Rainer J. Klement  and Colin E. Champ

Objective: To review studies to determine how calorie and carbohydrate restriction may influence the response to radiotherapy, using the 5R’s of radiobiology: repopulation, reoxygenation, intrinsic radiosensitivity, redistribution, and repair; for the purpose of influencing standard of nutrition care for cancer patients. (Read Full Review)



Nov 2013 | Effect of Exercising While Fasting On Eating Behaviors and Food Intake

November 8, 2013 | Journal of the International Society of Sports Nutrition 2013, 10:50  doi:10.1186/1550-2783-10-50
Surabhi Bhutani, Monica C Klempel, Cynthia M Kroeger, Eleanor Aggour, Yolian Calvo, John F Trepanowski, Kristin K Hoddy and Krista A Varady

Objective: The aim of this study was to examine the behavioral adaptations that occur when ADF  is combined with exercise, and to determine how these changes affect weight loss. (Read Full Study)



Oct 2013 – Alternate day fasting with or without exercise: Effects on endothelial function and adipokines in obese humans

European e-Journal of Clinical Nutrition and Metabolism (October 2013, Volume 8. Issue 5. Pages e205-e209)))
Surabhi Bhutani, Monica C. Klempel, Cynthia M. Kroeger, J.F. Trepanowski, Shane A. Phillips, Edita Norkeviciute, Krista A. Varady

Objective: Alternate day fasting (ADF; which consists of an ad libitum “feed day” alternated with a 75% energy restriction “fast day”) combined with exercise improves several coronary heart disease (CHD) risk factors. However, the effect of this combination therapy on endothelial function, and the role that adipokines play in mediating this effect, is unknown. Accordingly, this study examined the effect of ADF combined with exercise on brachial artery flow mediated dilation (FMD) and plasma adiponectin and leptin. (Read Full Study)




Jun 2013 | Effects of Dietary Glycemic Index on Brain Regions Related to Reward and Craving in Men. (Read Abstract)

June 26, 2013 | American Journal of Am J Clin Nutr. 2013 Sep;98(3):641-7. doi: 10.3945/ajcn.113.064113. Epub 2013 Jun 26
Lennerz BS, Alsop DC, Holsen LM, Stern E, Rojas R, Ebbeling CB, Goldstein JM, Ludwig DS

Objective: To examine the effects of the glycemic index (GI) on brain activity in the late postprandial period after a typical intermeal interval to evaluate hunger and craving thresholds in human subjects.




Mar 2013 – Alternate day fasting increases LDL particle size independently of dietary fat content in obese humans

European Journal of Clinical Nutrition (2013) 67, 783–785; doi:10.1038/ejcn.2013.83; published online 24 April 2013
M C Klempel, C M Kroegerand K A Varady

Objective: The goal of this study was to compared an ADF–HF (high fat) to an ADF–LF (low fat) diet on plasma lipids, LDL size and high-density lipoprotein (HDL) size. (Read Abstract)




Jul 2012 – Alternate day fasting (ADF) with a high-fat diet produces similar weight loss and cardio-protection as ADF with a low-fat diet

Metabolism Clinical and Experimental 62 (2013) 137-143
Monica C. Klempel, Cynthia M. Kroeger, Krista A. Varady

Objective: The goal of this study was to determine if these beneficial changes in body weight and coronary heart disease (CHD) risk can be reproduced in an HF (high fat) background diet is used in place of an LF diet during ADF. (Read Complete Study)




Apr 2012 | The WEIGH Study: Weighing Everyday to Improve and Gain Health (Read Study)

14 April 2012 | UNC Chapel Hill & Duke University
Dori M. Steinberg, MS, RD, Deborah F. Tate, PhD, Gary G. Bennett, PhD, Susan Ennett, PhD, Carmen Samuel-Hodge, PhD, RD, Dianne S. Ward, EdD

Objective:  Test whether a low-intensity intervention focusing on daily self-weighing can produce significantly greater weight loss compared to a delayed intervention control group.




Dec 2005 – Self-weighing in weight gain prevention and weight loss trials. (Read Abstract on PubMed)

Annals of Behavioral Medicine | 30 December 2005 | (3):210-6
Linde JA, Jeffery RW, French SA, Pronk NP, Boyle RG

Objective: To determine whether more frequent self-weighing exerts a positive influence on weight loss or weight gain prevention.






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